C3G provides structural bioinformatics services to help researchers explore the three-dimensional (3D) structure of biomolecules, integrating structural insights with genomic and functional studies. By leveraging computational modeling and simulation techniques, this service aids in understanding protein structure, stability, interactions, and mutation effects.

C3G’s structural bioinformatics pipeline includes:

• Structure visualization, allowing researchers to analyze macromolecular 3D conformations and functional domains.
• Mutation mapping, identifying structural changes caused by genetic variations and their potential effects on protein function.
• Molecular dynamics (MD) simulations, providing insights into the stability and flexibility of biomolecules under physiological conditions.
• Binding energy calculations, predicting molecular interactions, drug binding affinities, and ligand-protein stability.
• Contact maps, offering a graphical representation of atomic interactions within biomolecules, useful for studying protein folding and domain interactions.

By integrating structural bioinformatics with other genomic and transcriptomic data, C3G enables a multi-scale approach to studying gene function, protein interactions, and disease mechanisms.