Primary Function: The Agilent Triple Quad LCMS/MS Model 6460 Mass Spectrometer is a high-performance liquid chromatography-mass spectrometry/mass spectrometry (LCMS/MS) system designed for both routine and complex analyses, offering enhanced sensitivity, productivity, and precise quantification. It is a cutting-edge analytical platform for high-performance quantification, screening, and confirmation of analytes, capable of handling up to 100 overlapping compounds simultaneously.

Key Capabilities: This system features the innovative Agilent Jet Stream Technology, which uses super-heated nitrogen to collimate the nebulizer spray, dramatically increasing the number of ions entering the mass spectrometer, thereby reducing noise and boosting signals for enhanced sensitivity. It delivers femtogram-level detection limits, breaking the femtogram sensitivity barrier for many compounds, and offers a wide dynamic range of over 6.0 x 10^6. The 6460 ensures rapid data acquisition with scan speeds up to 12,500 Da/s and provides precise and accurate quantification results. Its advanced ion optics and collision cell technology enable efficient ion transmission and fragmentation, resulting in highly reproducible and precise data.

Applications:

1. Toxicology
2. Environmental analysis, including pesticide and herbicide analysis, and measuring trace-level environmental contaminants
3. Food safety, ensuring compliance with safety regulations for trace-level contaminants
4. Pharmaceutical analysis, supporting drug development, impurity profiling, and quantifying pharmaceutical candidates
5. Drugs of abuse testing
6. Confirming biomarkers
7. Compound confirmation and identification of potential drug molecules
8. High throughput ADME assays (metabolic stability, membrane transport, drug-drug interactions, initial toxicology screening)
9. Rapid identification of metabolites
10. Bioanalysis for quantitation of drug compounds in biological matrices
11. Impurity analysis during drug development
12. Clinical research and analysis
13. Peptide quantitation
14. Forensics
15. Analysis of small molecules, extractables & leachables from plastics & polymers, and textile fabrics