The BIC PET Imaging Unit provides a diverse range of positron emission tomography (PET) tracers for neuroscience, oncology, and metabolic imaging applications. These radiolabeled compounds enable quantitative imaging of neurotransmitter systems, receptor binding, inflammation, and metabolic activity in human research.

📌 For inquiries regarding additional tracer production, please contact the Director of Cyclotron.

Neuroreceptor Imaging Tracers

🔹 [11C]ABP688 – mGluR5 Receptor Imaging

✔ Selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist

✔ Used in glutamatergic system research

🔹 [11C]FLB 457 – Dopamine D2 Receptor Imaging (Extrastriatal)

✔ High-affinity ligand for D2 receptors in extrastriatal brain regions

✔ Used in neuropsychiatric disorder research

🔹 [11C]Raclopride – Dopamine D2 Receptor Antagonist

✔ Imaging of striatal dopamine D2 receptors

🔹 [11C]SCH 23390 – Dopamine D1 Receptor Antagonist

✔ Specific for D1 receptor mapping in neuropsychiatric research

🔹 [11C]UCB-J – Synaptic Density Imaging

✔ Binds to synaptic vesicle glycoprotein 2A (SV2A), a marker of synaptic density

✔ Used in epilepsy and neurodegenerative disorder studies

🔹 [11C]CIMBI36 – Serotonin 5-HT2A Receptor Agonist

✔ PET radioligand for serotonin 5-HT2A receptor mapping

✔ Used in addiction and mood disorder research

🔹 [18F]Fallypride – Dopamine D2 Receptor Antagonist

✔ High-affinity D2 receptor ligand, allowing visualization in cortical and subcortical regions

🔹 [18F]MPPF – Serotonin 5-HT1A Receptor Ligand

✔ Used in serotonin system research

🔹 [18F]Altanserin – Serotonin 5-HT2A Receptor Ligand

✔ PET marker for serotonin receptor imaging

🔹 [18F]Benzovesamicol – Vesicular Acetylcholine Transporter (VAChT) Imaging

✔ Investigational radioligand for cholinergic system research

Neurodegenerative Disease & Tau Imaging Tracers

🔹 [11C]PIB – Amyloid Plaque Imaging

✔ Gold-standard PET tracer for beta-amyloid imaging in Alzheimer’s disease

🔹 [18F]NAV4694 – Beta-Amyloid Imaging

✔ Next-generation amyloid PET ligand

🔹 [18F]T807 – Tau Protein Imaging

✔ PET imaging agent for Tau deposition in Alzheimer’s and related tauopathies

🔹 [18F]MK6240 – Tau Imaging (2nd Gen)

✔ Improved tau pathology detection in dementia research

🔹 [18F]PI2620, [18F]RO6958948, [18F]THK5351 – 2nd Generation Tau Tracers

✔ Advanced tau PET imaging for neurodegenerative diseases

Neuroinflammation & Microglia Activation Tracers

🔹 [11C]PBR28 – Translocator Protein (TSPO) Ligand

✔ Microglial activation marker, used in neuroinflammation imaging

🔹 [11C]PK 11195 – TSPO Ligand (1st Gen)

✔ Classic TSPO tracer for neuroinflammatory conditions

🔹 [18F]PBR06, [18F]DPA714 – Next-Gen TSPO Tracers

✔ Improved TSPO imaging with reduced non-specific binding

🔹 [18F]JNJ-64413739 – P2X7 Ion Channel PET Ligand

✔ Investigational ligand for neuroinflammatory pathways

Metabolic & Tumor Imaging Tracers

🔹 [18F]FDG – Glucose Metabolism Imaging

✔ Standard PET tracer for metabolic studies and cancer detection

🔹 [18F]FECh – Prostate Cancer Imaging

✔ Fluoroethyl-choline PET tracer for prostate cancer detection

🔹 [18F]FMCh – Choline Metabolism in Tumors

✔ Investigational tracer for tumor imaging

🔹 [18F]FMISO – Hypoxia Imaging

✔ Fluoromisonidazole PET tracer for detecting hypoxic tumor regions

Blood Flow & Other Functional Imaging Tracers

🔹 [15O]Water – Cerebral Blood Flow Imaging

✔ Standard tracer for regional cerebral blood flow (rCBF) measurement

🔹 [11C]alpha-Methyl-L-Tryptophan – Serotonin Synthesis

✔ Used in serotonin metabolism research

🔹 [18F]Flumazenil – GABA-A Receptor Imaging

✔ Ligand for central benzodiazepine receptors (cBZR) on GABA-A receptors