The Abberior STED (Stimulated Emission Depletion) Super-resolution Nanoscope is a cutting-edge microscopy system built on an inverted microscope body (e.g., Olympus IX83), offering both confocal and super-resolution capabilities. It achieves sub-diffraction resolution down to approximately 25 nm in XY and 80 nm in XYZ, enabling detailed visualization of cellular structures at the nanoscale. The system features multiple excitation lasers (e.g., 405nm, 485nm, 561nm, 640nm) and pulsed STED lasers (e.g., 595nm, 775nm) for 2D and 3D depletion. It is equipped for live-cell imaging with features like RESCue mode to minimize photobleaching and phototoxicity, FLIM (Fluorescence Lifetime Imaging Microscopy) and FCS (Fluorescence Correlation Spectroscopy) acquisition capabilities, and adaptive optics for improved image quality in thicker samples. High-sensitivity APD detectors ensure efficient photon collection.