The Zeiss LSM 880 with Airyscan is a high-performance confocal laser scanning microscope capable of generating three-dimensional, super-resolution images of both fixed and live samples. Its unique Airyscan detector, based on a 32 GaAsP photosensitive elements honeycomb array, significantly increases sensitivity (4x-8x) and resolution (1.7x improvement, e.g., 140nm lateral and 400nm axial resolution at 488nm excitation) by bypassing the pinhole. This system is particularly well-suited for dynamic live-cell imaging due to its ability to achieve faster temporal super-resolution imaging with lower laser power, minimizing phototoxicity. It features various laser lines (e.g., 355nm, 405nm, 458nm, 488nm, 514nm, 561nm, 594nm, 633nm), multiple detectors (GaAsP, PMT, Airyscan), and environmental control capabilities (temperature, CO2) for long-term experiments. It supports applications such as z-stack, time series, tile scan, multi-position imaging, spectral detection, and FRAP.