Pall Centramate 500-S Tangential Flow Filtration System

Primary Function: The Pall Centramate 500-S Tangential Flow Filtration System is a versatile benchtop unit engineered for efficient ultrafiltration (UF) and microfiltration (MF) applications. It is designed for the concentration, diafiltration, separation, and purification of a wide range of biomolecules and particulates.

Key Capabilities: This system excels in achieving high concentration factors and optimal product recovery due to its low hold-up volume and hygienic, fully drainable flow path. It supports process development with linear scalability to larger Pall Centramate and Centrasette cassette holders, making it suitable for transitioning from lab-scale to pilot and production environments. The system also features data logging capabilities, allowing process instrumentation data to be exported via USB for analysis.

Design and Compliance: Featuring a sanitary, self-venting, and fully drainable design, the Centramate 500-S meets the stringent demands of cGMP environments, ensuring full traceability of process-wetted materials. Its ultra-compact and portable nature makes it ideal for various laboratory and biopharmaceutical settings.

Applications: Beyond general ultrafiltration and microfiltration, the system is widely used in biopharmaceutical drug development and manufacturing, including the concentration and diafiltration of suspended microparticulates (such as cell suspensions and lysates) and dissolved solutes (like proteins or nucleic acids). Specific applications include the harvest, concentration, and clarification of cell cultures and fermentation broths, separation of red blood cells from hemoglobin, and clarification of yeast broth and bacterial lysates. It is also valuable for biopharmaceutical small batch production, scale-down investigations, and the generation of materials for safety and efficacy studies (Phase I clinicals).