Human Airway Fibroblast cells are primary cells derived from the human airway. These cells are integral to the structural integrity of the airway and play a critical role in airway remodeling, particularly in chronic respiratory diseases such as asthma and COPD. Fibroblasts contribute to the extracellular matrix production and can differentiate into myofibroblasts, influencing airway smooth muscle function and overall airway mechanics. They are used in research to study inflammation, tissue repair, fibrosis, and the cellular and molecular mechanisms underlying airway wall thickening and remodeling.