The Douglas Neurophenotyping Centre is a specialized research facility designed to comprehensively study how specific genes, environmental influences, and stress interact to modify brain function, behavior, and cognitive abilities in animal models of mental pathologies. Its primary function is to provide expert behavioral testing, data analysis, and interpretation services for rodent models, offering critical insights into the complex interplay of genetic and environmental factors in mental health. The center is extensively equipped to conduct a wide array of behavioral tests, covering domains such as anxiety, memory and learning, motor function, nociception (pain), drug effects, stress responses, and impulsivity. It boasts high-throughput capabilities for mouse colony phenotyping and genotyping. The facility spans over 15,000 square feet, housing up to 3,000 rats and mice, and includes specialized areas such as semi-natural environments, dedicated behavior analysis laboratories, tissue analysis rooms, and gene therapy rooms. Robust quarantine facilities are also in place to ensure the safe integration of animals from diverse sources. This platform is crucial for complementing molecular, cellular, and imaging studies, enabling researchers to gain a holistic understanding of the mechanisms underlying mental illness. Its applications span various research areas, including neurodevelopmental disorders, schizophrenia, autism spectrum disorder, ADHD, Alzheimer's disease, and Parkinson's disease. The center allows investigators to explore sophisticated animal models of human diseases and to identify environmental factors that may trigger disease onset or progression. To further support research, the Neurophenotyping Centre offers full-service packages that encompass animal breeding, genotyping, and experimental execution. It also provides valuable assistance with experimental design, particularly for studies integrating small animal MRI and behavioral phenotyping. All operations are conducted in strict adherence to animal use protocols approved by the McGill University Animal Ethics Committee and comply with the guidelines of the Canadian Council on Animal Care (CCAC), ensuring the highest standards of animal welfare and ethical research.