Cardiomyocyte differentiation
The core differentiates human iPS cells into cardiomyocytes by one of two routes: modulating Wnt signaling, or with a STEMCELL Technologies kit.
You provide
- Starting materialBlood, skin fibroblasts, an existing iPS cell line, or one of the core's lines
- Protocol or earlier data
Request this service
Stem Cell Core replies with scope and price.
Your details
Your lab
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Nothing is booked or charged until you accept a quote.
You receive
- Cardiomyocytes differentiated from your human iPS cells
How it goes
You ask
Answer a few questions about your samples.
They scope it
The facility confirms it can be done and may ask for a detail or two.
You accept a quote
Price and timing, agreed before any work starts.
Results come back
Files arrive in your requests, with a note from the facility.
Where it's been used
Gene-edited WTC iPS cells turned into heart muscle cells, to test a common BAG3 variant linked to protection from heart failure.
Functional analysis of a common BAG3 allele associated with protection from heart failure
Perez-Bermejo, Judge, Jensen, et al. · Nature Cardiovascular Research · 2023
WTC11 iPS cells turned into cardiac progenitors, used to show how GATA4 binds RNA and shapes splicing in developing heart cells.
Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors
Zhu, Choudhary, Gonzalez-Teran, et al. · Circulation · 2022
WTC iPS cells turned into heart muscle cells, cardiac fibroblasts and endothelial cells, to study how SARS-CoV-2 damages the heart.
SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19
Perez-Bermejo, Kang, Rockwood, et al. · Science Translational Medicine · 2021
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